Research journal accepted similar findings by Human Genome Project manager nearly two years ago but held paper indefinitely for “research integrity” review. Some scientists question claim of no “adverse outcomes.”
Three years after federal regulators granted emergency use authorization to COVID-19 mRNA vaccines for older teens and adults, mainstream scientific research is confirming suppressed warnings from two years ago that the novel technology has a problem with “translation fidelity.”
Translation: it tends to make a bunch of wacky “off-target” proteins whose effects and severity are unknown.
The University of Cambridge paper, published in Nature this month, found that Pfizer’s vaccine increased “ribosomal frameshifting,” in which proteins are copied incorrectly in “slippery sequences” of code.
The vaccine technology relies on replacing the RNA base uridine, which provokes the body to attack the jab, with a synthetic version, according to The Telegraph report on the U.K. government-funded research.
The ribosome “slips around 10% of the time” when it confronts N1-methylpseudouridine modified bases, “causing the mRNA to be misread and unintended proteins to be produced – enough to trigger an immune response” in a third of the study’s 21 subjects, the University of Cambridge release says.
While the paper’s authors said they found no association with “adverse outcomes,” they called for modifying mRNA sequence design to reduce frameshifting, “as this may limit its future use for applications that require higher doses or more frequent dosing.”